Sara Wickström

Sara Wickström's picture
Paul Gerson Unna Group Leader
Max Planck Institute for Biology of Ageing, Cologne

Frontiers in Skin Biology & Dermatology

Lecture Title: Biomechanical Regulation of Epidermal Stem Cell Fate
Date: Friday 29 September 2017, 10.05-10.30

Research Focus

  • Role of stem cell-niche interactions in fate decisions and phenotypic plasticity
  • Biomechanics of epidermal morphogenesis, homeostasis and ageing
  • Regulation of nuclear and genomic architecture, gene expression, and SC fate by mechanotransduction

More information (external link)

Selected publications

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment
Le, H. Q.Ghatak, S.Yeung, C. Y.Tellkamp, F.Gunschmann, C.Dieterich, C.Yeroslaviz, A.Habermann, B.Pombo, A.Niessen, C. M.Wickstrom, S. A.
(2016) Nat Cell Biol, 18, 8, 864-75

Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny
Chacon-Martinez, C. A.Klose, M.Niemann, C.Glauche, I.Wickstrom, S. A.
(2016) EMBO J

Integrin-linked kinase regulates the niche of quiescent epidermal stem cells
Morgner, J.Ghatak, S.Jakobi, T.Dieterich, C.Aumailley, M.Wickstrom, S. A.
(2015) Nat Commun, 6, 8198

Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response
Radovanac, K.*Morgner, J.*Schulz, J. N.Blumbach, K.Patterson, C.Geiger, T.Mann, M.Krieg, T.Eckes, B.Fassler, R.Wickstrom, S. A.
(2013) EMBO J, 32, 10, 1409-24

Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae
Wickstrom, S. A.**Lange, A.Hess, M. W.Polleux, J.Spatz, J. P.Kruger, M.Pfaller, K.Lambacher, A.Bloch, W.Mann, M.Huber, L. A.Fassler, R.
(2010) Dev Cell, 19, 4, 574-88