Maria Sibilia

Maria Sibilia's picture
Group Leader: Cellular and Molecular Tumor Biology
Medical University of Vienna

Frontiers in Skin Biology & Dermatology

Lecture Title: Cell-Specific Functions of Epidermal Growth Factor Receptor (EGFR) Signaling in Inflammation and Cancer
Date: Thursday 28 September 2017

Research Focus

Tumors are increasingly being recognized as organs consisting of cancer cells and a variety of cells composing the ”tumor microenvironment” which include immune cells, vascular cells and fibroblasts. These stromal cells significantly contribute to malignant progression. Using the mouse as a model system her group aims to understand the role of Epidermal Growth Factor Receptor (EGFR) signaling in cancer cells, in tumor stromal cells and their complex interaction. The ultimate goal is to translate this knowledge to human patients to develop rational and effective therapies for the treatment of human cancer.

More information (external link)

Selected Publications

Specific roles for dendritic cell subsets during initiation and progression of psoriasis.
Glitzner E, Korosec A, Brunner PM, Drobits B, Amberg N, Schonthaler HB, Kopp T, Wagner EF, Stingl G, Holcmann M, Sibilia M.; EMBO Mol Med. 2014 Sep 12;6(10):1312-27

EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation.
Lanaya H, Natarajan A, Komposch K, Li L, Amberg N, Chen L, Wculek SK, Hammer M, Zenz R, Peck-Radosavljevic M, Sieghart W, Trauner M, Wang H, Sibilia M.; Nat Cell Biol. 2014 Oct; 16(10):972-81, 1-7.

Epidermal EGFR controls cutaneous host defense and prevents inflammation.
Lichtenberger BM, Gerber PA, Holcmann M, Buhren BA, Amberg N, Smolle V, Schrumpf H, Boelke E, Ansari P, Mackenzie C, Wollenberg A, Kislat A, Fischer JW, Röck K, Harder J, Schröder JM, Homey B, Sibilia M.; Sci Transl Med. 2013 Aug 21; 5(199):199

Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells.
Drobits B, Holcmann M, Amberg N, Swiecki M, Grundtner R, Hammer M, Colonna M, Sibilia M.; J Clin Invest. 2012 Feb 1; 122(2):575-85.   

Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development.
Lichtenberger BM, Tan PK, Niederleithner H, Ferrara N, Petzelbauer P, Sibilia M.; Cell. 2010 Jan 22; 140(2):268-79.