Juha Kere

Juha Kere's picture
Professor/Senior Physician, Department of Biosciences and Nutrition (BioNut)
Karolinska Institute, Huddinge

Frontiers in Skin Biology & Dermatology

Lecture Title: Keratinocyte Transcriptomics from Skin Biopsies to Single Cells
Date: Thursday 28 September 2017

Research Focus

Professor Kere's research focuses on the discovery of gene effects in complex human phenotypes, functional annotation of genes and characterization of gene networks in selected diseases. Three major projects involve the epigenetics and genetics of asthma and allergies (EpiGene project; Reinius & al. 2012, see selected publications), gene networks in dyslexia (Massinen & al. 2011, Tammimies & al. 2012), and human embryonal development from oocyte to implantation (unpublished). In addition, his group has been characterizing the population structure of Sweden and Finland (Salmela & al. 2011).

His group is interdisciplinary and includes members with solid background in genetics, biochemistry, molecular and cellular biology, biostatistics, bioinformatics, and model systems (mouse and zebrafish). They have close collaborations with clinical specialists and epidemiologists as well as leading experts on special methodologies, such as single-cell transcriptomics and brain imaging, and are involved in international consortia. His group uses modern genomics tools such as high-throughput sequencing for discovering gene variants and for gene expression profiling (RNAseq).

Selected Publications

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
Joubert Br, Felix Jf, Yousefi P, Bakulski Km, Just Ac, Breton C, et al
American journal of human genetics 2016;98(4):680-96

Genomic sequencing of a dyslexia susceptibility haplotype encompassing ROBO1
Massinen S, Wang J, Laivuori K, Bieder A, Tapia Paez I, Jiao H, et al
Journal of neurodevelopmental disorders 2016;8():4-

Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease
James Aj, Reinius Le, Verhoek M, Gomes A, Kupczyk M, Hammar U, et al
American journal of respiratory and critical care medicine 2016;193(2):131-42

NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis
Tervaniemi Mh, Katayama S, Skoog T, Siitonen Ha, Vuola J, Nuutila K, et al
Scientific reports 2016;6():22745-

Single-cell transcriptome analysis of endometrial tissue
Krjutškov K, Katayama S, Saare M, Vera-rodriguez M, Lubenets D, Samuel K, et al
Human reproduction (Oxford, England) 2016;31(4):844-53

Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts
Conte S, Katayama S, Vesterlund L, Karimi M, Dimitriou M, Jansson M, et al
British journal of haematology 2015;171(4):478-90

Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes
Acevedo N, Reinius Le, Vitezic M, Fortino V, Söderhäll C, Honkanen H, et al
Clinical epigenetics 2015;7():34-

A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease
Kyöstilä K, Syrjä P, Jagannathan V, Chandrasekar G, Jokinen Ts, Seppälä Eh, et al
PLoS genetics 2015;11(4):e1005169-

Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts
Fuertes E, Söderhäll C, Acevedo N, Becker A, Brauer M, Chan-yeung M, et al
The Journal of allergy and clinical immunology 2015;135(2):573-6

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
Haapaniemi Em, Kaustio M, Rajala Hl, Van Adrichem Aj, Kainulainen L, Glumoff V, et al
Blood 2015;125(4):639-48